| dc.contributor.author |
Addy, Partha Sarathi |
|
| dc.date.accessioned |
2021-11-11T10:55:41Z |
|
| dc.date.available |
2021-11-11T10:55:41Z |
|
| dc.date.issued |
2013-02-20 |
|
| dc.identifier.uri |
https://www.sciencedirect.com/science/article/pii/S0040403912020655 |
|
| dc.identifier.uri |
http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/3312 |
|
| dc.description.abstract |
Two 10-membered benzo-fused N-substituted cyclic enediynes, one an amino methyl and the other, a C-lysine conjugated derivative 2 and 3, respectively were synthesized (as a 1.2:1 mixture of regioisomers) and their DNA-cleavage efficiency studied. Both the compounds showed much better DNA-cleavage profile than that of the parent unsubstituted enediyne 1. The lysine conjugate 3 showed an efficient pH dependent cleavage to the extent of ∼50% of linear DNA formation under ambient conditions. |
en_US |
| dc.language.iso |
en |
en_US |
| dc.publisher |
Elsiever |
en_US |
| dc.subject |
Chemistry |
en_US |
| dc.subject |
Synthesis |
en_US |
| dc.subject |
L-lysine conjugate |
en_US |
| dc.title |
Synthesis of highly efficient pH-sensitive DNA cleaving aminomethyl N-substituted cyclic enediyne and its L-lysine conjugate |
en_US |
| dc.type |
Article |
en_US |