| dc.contributor.author |
Bajaj, Kiran |
|
| dc.date.accessioned |
2021-11-11T11:24:58Z |
|
| dc.date.available |
2021-11-11T11:24:58Z |
|
| dc.date.issued |
2003 |
|
| dc.identifier.uri |
https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0031-1297113 |
|
| dc.identifier.uri |
http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/3521 |
|
| dc.description.abstract |
2-Amino-5-(heteroarylmethylene)-1,3,4-oxadiazoles/thiadiazoles 7−10 were synthesized by cyclisation of 1-(heteroarylacetyl)semicarbazides/thiosemicarbazides 3−6. 5-(2’-Heteroarylmethylene-5’-aminomethylene-1’, 3’, 4’-oxadiazol-2’-yl/ thiadiazol-2’-yl)-2-oxo/thiobarbituric acids 11−18 were synthesized by condensation of compounds 7−10 at the 5th position of 2-oxo/thiobarbituric acids. The newly synthesized compounds showed anticonvulsant activity ranging from 50–90 % (seizures protection). Compound 18 (5-(2’-phenothiazinylmethylene-5’-aminomethylene-1’,3’,4’-thiadiazol-2’-yl)-2-thiobarbituric acid) showed maximum activity being more potent than the reference drug phenytoin sodium (CAS 630-93-3) |
en_US |
| dc.language.iso |
en |
en_US |
| dc.publisher |
Thieme |
en_US |
| dc.subject |
Chemistry |
en_US |
| dc.subject |
Synthesis |
en_US |
| dc.subject |
Oxo/thiobarbituric acid derivatives |
en_US |
| dc.subject |
Anticonvulsant acitvity |
en_US |
| dc.title |
Synthesis of Newer Indolyl/ Phenothiazinyl Substituted 2-Oxo/ Thiobarbituric Acid Derivatives as Potent Anticonvulsant Agents |
en_US |
| dc.type |
Article |
en_US |