Synthesis and Photocytotoxicity Studies of Some Novel Porphyrin Heterocycles

Abstract

Porphyrinoids have found promising applications as photosensitizers in photodynamic therapy and newlinephotodynamic imaging due to their unique absorption and emission properties in visible region 400800 nm newlineAlso their ability to absorb light and transfer its energy to molecular oxygen to produce reactive oxygen newlinespecies ROS such as singlet oxygen and superoxide radicals which initiate a series of complex chemical and newlinebiological events that ultimately leads to cell death Porphyrins and metalloporphyrins are also ideal model newlinecompounds for studying light harvesting energy and electron transfer and redox catalysis This thesis newlinedescribes the synthesis absorptionemission and photocytotoxicity properties of some novel porphyrin newlineconjugates and porphyrinbased heterocycles newlineThe thesis entitled Synthesis and biological Studies of some novel porphyrins and their conjugates is divided newlineinto four chapters The first chapter Introduction provides some insight about natural occurrence of newlineporphyrins their nomenclature and photophysical properties A detailed review of classical synthetic routes to newlinethe most recent improvements to achieve simple as well as complex porphyrin systems has been provided newlineParticularly porphyrinbased photosensitizers currently in market and several others in clinical trials have also newlinebeen elaborated along with their mechanism of action newlineThe second chapter unveils design synthesis and photocytotoxicity studies of some cationic porphyrin newlineconjugates The work embodied in this chapter has been divided into four parts Part A Part B Part C and Part newlineD Part A reports an iodineIIImediated facile synthesis of 4and#8242;cyanophenylporphyrins from readily newlineavailable porphyrin thioamides Two novel cationic cyanoporphyrins displayed efficient photonuclease activity newline1 and#956;M and their absorption and emission studies.