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BITS Pilani Institutional Repository: Recent submissions

Now showing items 1701-1720 of 18741

Photolysis of azocyclohexane alone and in an oxygen atmosphere

Currie, James L.; Sidebottom, Howard W.; Tedder, John M. (Journal of the Chemical Society : Faraday Transaction - I. The Chemical Society, London. 1974, 70 (10), 1974)

The photolysis of azocyclohexane involves excited molecules which can be deactivated by collision or decompose into cyclohexyl radicals and nitrogen. Arrhenius parameters for reaction (11) have been estimated, cyclo-C6H1 ...
Addition of ethyl radicals to nitric oxide

Pratt, Graham; Veltman, Ian (Journal of the Chemical Society : Faraday Transaction - I. The Chemical Society, London. 1974, 70 (10), 1974)

Mixtures of methyl and ethyl radicals have been generated at 295 K in a fast flow discharge system by addition of hydrogen atoms to ethylene in helium at total pressures from 6 to 15 Torr (1 Torr = 133 N m–2). Mass ...
Chemisorption of nitrogen on tungsten studied by auger electron spectroscopy

Joyner, Richard W.; Rickman, John; Roberts, M. Wyn (Journal of the Chemical Society : Faraday Transaction - I. The Chemical Society, London. 1974, 70 (10), 1974)

By monitoring the surface directly by Auger electron spectroscopy (AES), adsorption isotherms for nitrogen on polycrystalline tungsten ribbons have been determined in the temperature range 1200–1400 K. These are not of the ...
Evidence for the nature of CO adsorbed on nickel from electron spectroscopy

Joyner, Richard W.; Roberts, M. Wyn (Journal of the Chemical Society : Faraday Transaction - I. The Chemical Society, London. 1974, 70 (10), 1974)

At 295 K there is clear evidence from the observed X-ray and u.v. induced spectra that CO is adsorbed in a molecular form. The observed spectra are in good agreement with the ionisation potentials expected of electrons in ...
Site-binding model of the electrical double layer at the oxide/water interface

Yates, David E.; Levine, Samuel; Healy, Thomas W. (Journal of the Chemical Society : Faraday Transaction - I. The Chemical Society, London. 1974, 70 (10), 1974)

A site-binding model of the oxide/aqueous electrolyte interface is introduced, in which it is proposed that the adsorbed counter ions form interfacial ion pairs with discrete charged surface groups. This model is used to ...
Electric Modulated Reflectance at Mercury Electrodes: Transition between Electrostatic Adsorption and Chemisorption

Gottesfeld, Shimshon; Conway, Brian E. (Journal of the Chemical Society : Faraday Transaction - I. The Chemical Society, London. 1974, 70 (10), 1974)

Reflectance changes at polished electrode surfaces can arise from changes of optical properties of the metal surface and from changes of local ionic concentrations in the double-layer. The significance of these two effects ...
Homogeneous Isotope Exchange Reactions: Part 3—H2S+D2

Pratt, Graham; Rogers, David (Journal of the Chemical Society : Faraday Transaction - I. The Chemical Society, London. 1977, 73 (1), 1977)

The kinetics of the early stages of the exchange reaction in H2S + D2 mixtures [H2S, 0.55–9.34 Torr (1 Torr = 133 N m–2); D2, 0.55–6.39 Torr] have been studied in a static system at 808–937 K. The effects of excess argon ...
Standard Free Energy of Transfer of Ionic Surfactants from Water to Water+Acetone Mixtures from Vapour Pressure Measurements

Treiner, Claude; Besnerais, A. Le (Journal of the Chemical Society : Faraday Transaction - I. The Chemical Society, London. 1977, 73 (1), 1977)

The standard free energy of transfer, ΔG°t of sodium decylsulphate (SDS) and of decyltrimethyl-ammonium bromide (DTMABr) from pure water to mixtures of water and acetone (AC) have been determined by accurate vapour pressure ...
Label-free GaN HEMT-based biosensing platform for interferon-γ detection

Taliyan, Rajeev (Elsevier, 2024-08)

Intracranial injury such as traumatic brain injury is caused by sudden injury to the brain from external mechanical force causing health loss and disability worldwide. The work reports the design and development of a GaN ...
Pharmacokinetic and Biodistribution Studies of Camel Milk Casein Nanoparticles Loaded Sorafenib in Swiss Albino Mice

Taliyan, Rajeev; Dubey, Uma S. (Springer, 2024-06)

Sorafenib, a multikinase inhibitor, is used for the treatment of advanced stages of hepatic and renal carcinoma patients. However, sorafenib’s low solubility, low bioavailability, unfavorable pharmacokinetic properties, ...
Immunological challenges and opportunities in glioblastoma multiforme: A comprehensive view from immune system lens

Singhvi, Gautam; Taliyan, Rajeev (Elsevier, 2024-11)

Glioblastoma multiforme (GBM), also known as grade IV astrocytoma, is the most common and deadly brain tumour. It has a poor prognosis and a low survival rate. GBM cells' immunological escape mechanism helps them resist ...
Neuroprotective potential of Epigenetic modulators, its regulation and therapeutic approaches for the management of Parkinson's disease

Taliyan, Rajeev (Elsevier, 2024-12)

The progressive degeneration of dopaminergic neurons in the substantia nigra region of the brain leads to a deficiency of dopamine and, ultimately, the onset of Parkinson's disease (PD). Since there is currently no cure ...
Millions of people worldwide are negatively impacted by a diverse range of brain conditions known as neurodegenerative diseases. The work reports a GaN HEMT-based biosensing system for the early detection and monitoring of neurodegenerative disease biomarkers in clinically relevant concentration ranges. The developed system offers a high sensitivity of 19.40 µA/pg/ml, 0.52 mA/pg/ml, 0.69 mA/ng/ml, 0.13 mA/pg/ml, 23.66 µA/pg/ml, and 23.85 µA/pg/ml for the detection of UCH-L1, GFAP, S100B, IL-6, Aβ, and IFN-γ respectively. The proposed biofunctionalization assay has an excellent specificity and selectivity, signal-to-noise ratio of 1:16, 1:23, and 1:38 for UCH-L1, GFAP, and S100B detection respectively with a LoD of 0.06 fg/ml. The platform has good repeatability with an average sensitivity of 19.41 µA/pg/ml, 0.524 mA/pg/ml, and 0.704 mA/ng/ml for UCH-L1, GFAP, and S100B detection respectively. The sensors have a very good shelf-life for a storage time of 35 days with reductions of 1.39 %, 1.72 %, and 2.05 % in sensor response and 2.88 %, 2.76 %, and 2.96 % in sensitivity for UCH-L1, GFAP, and S100B respectively. The coefficient of variation (CV) values for conventional and meander-gated GaN HEMT biosensors were found to be ∼0.038 and ∼0.026 respectively. A slight variation of ∼4.41 % in sensor response when the sensor was reused clearly demonstrates the sensor’s reusability. A very high resolution with detection capability in the ultra-low concentration of fg/ml with good linearity and quantifiable sensor response which is a key requirement for early-stage detection of diseases has been observed for sensor design with source-to-drain distance () of 10 µm. Thus, the platform capability and suitability for early detection and prognosis of neurodegenerative disease detection and monitoring have been demonstrated. Further, the system can be imperative in patient screening in clinical, sports, and warfare for CT or MRI scan requirements.

Taliyan, Rajeev (Elsevier, 2025-01)

Psychiatric disorders pose a significant global health challenge, exacerbated by the COVID-19 pandemic and insufficiently addressed by the current treatments. This review explores the emerging role of bile acids and the ...
Neurodegenerative diseases early detection and monitoring system for point-of-care applications

Taliyan, Rajeev (Elsevier, 2025-01)

Millions of people worldwide are negatively impacted by a diverse range of brain conditions known as neurodegenerative diseases. The work reports a GaN HEMT-based biosensing system for the early detection and monitoring ...
Design aspects, development, and sensitivity analysis of gan hemt-based biosensing platform for label-free detection of interleukin-6

Taliyan, Rajeev (IOP, 2025)

Severe TBI survivors face long-term brain damage requiring accurate diagnosis and early treatment as the therapeutic time window typically ranges from minutes to hours before the secondary injury. In this work, we report ...
Chitinase-3-like-1: a multifaceted player in neuroinflammation and degenerative pathologies with therapeutic implications

Taliyan, Rajeev (Springer, 2025-01)

Chitinase-3-like-1 (CHI3L1) is an evolutionarily conserved protein involved in key biological processes, including tissue remodeling, angiogenesis, and neuroinflammation. It has emerged as a significant player in various ...
Kynurenine monooxygenase inhibition and associated reduced quinolinic acid reverses depression-like behaviour by upregulating Nrf2/ARE pathway in mouse model of depression: In-vivo and In-silico studies

Khare, Pragyanshu (Elsevier, 2022-09)

Kynurenine pathway, a neuroimmunological pathway plays a substantial role in depression. Consistently, increased levels of neurotoxic metabolite of kynurenine pathway; quinolinic acid (QA) found in the suicidal patients ...
Topical menthol, a pharmacological cold mimic, induces cold sensitivity, adaptive thermogenesis and brown adipose tissue activation in mice

Khare, Pragyanshu (Wiley, 2024-07)

Brown adipose tissue (BAT) thermogenesis has profound energy-expanding potential, which makes it an attractive target tissue to combat ever-increasing obesity and its other associated metabolic complications. Although it ...
The TRPC5 receptor as pharmacological target for pain and metabolic disease

Khare, Pragyanshu (Elsevier, 2024-11)

The transient receptor potential canonical (TRPC) channels are a group of highly homologous nonselective cation channels from the larger TRP channel family. They have the ability to form homo- and heteromers with varying ...
Nanoparticle-based materials for wound management

Pandey, Murali Monohar (Elsevier, 2024)

Nanotechnology is an approach where nanoscale materials are biomedically used for the prevention of various diseases and infections. Their smaller size and larger surface area make them appropriate for various applications. ...

Now showing items 1701-1720 of 18741

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