Department of Pharmacy
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Item Disulfiram potentiates docetaxel cytotoxicity in breast cancer cells through enhanced ROS and autophagy(Springer, 2020-07) Chowdhury, Rajdeep; Roy, AniruddhaRecent studies have demonstrated that autophagy plays a critical role in reducing the drug sensitivity of docetaxel (DTX) therapy. Disulfiram (DSF) has exhibited potent autophagy inducing activity in multiple studies. We hypothesized that DSF co-treatment could sensitize breast cancer cells to DTX therapy via autophagy modulation.