Department of Pharmacy

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Author: search.filters.author.Jain, AnkitSubject: search.filters.subject.Cancer

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    Lineage of lipid-based endosomal escape in cytosolic delivery to cancer: insight into an unprecedented approach
    (Elsevier, 2025-12) Jain, Ankit
    Endosomal sequestration of lipid-based systems constitutes a significant limitation that undermines the efficient intracellular delivery of therapeutics in cancer treatment. Upon administration, the intracellular fate of drug or gene constructs within lipid-based delivery systems is influenced by various factors, including p-glycoprotein-mediated efflux and lysosomal degradation, which impede sufficient therapeutic agents from reaching their intended targets. This review exhaustively discusses lipids (properties of lipids and role of pKa) and various lipid-based delivery systems facilitating the endosomal escape for cancer treatment. All aspects, such as endosomal sequestration, methods to promote endosomal escape, a mechanistic overview of endosomal escape, detection of endosomal escape, the application potential of lipid-based systems for cancer treatment, and safety of lipid-based systems, were covered in this manuscript. Existing reviews on endosomal escape have accounted for the various mechanisms,. Still, this review paper also furnishes the role of pKa and applications of molecular dynamic simulation in lipid-based drug delivery, and safety concernsof lipid-based nanosystems. This review discussed the influence of material properties on the endosomal escape of therapeutic agents.
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    Liposomal delivery system
    (Springer, 2022-03) Jain, Ankit
    Liposomes are biodegradable and biocompatible lipid bilayer vesicles that are employed as potential carriers for the delivery of drugs to the desired site. It is used for the delivery of both hydrophobic and hydrophilic drugs. Because of the variability in composition and structural properties, liposomes are widely used in biomedical applications. Recently, multifunctional liposomes have been reported for tumor targeting. Liposomal delivery systems are modified in several ways according to their applications. Ligand-modified liposomes are used for targeted drug delivery. Stimuli-sensitive liposomes are used to obtain the trigger drug release at the site of action. Theranostic liposomal systems are used for diagnosis as well as therapeutic purposes. This chapter highlights the basics and classification of liposomes. It encompasses a detailed account of ligand targeted liposomes (such as folate, transferrin, mannose, hyaluronic acid, and asialoglycoprotein), and stimuli-sensitive liposomes (such as pH, temperature, magnetic field, hypoxia, and photo-triggered) for tumor targeting. It also includes some marketed liposomal products used for cancer treatment
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    A glimpse of biomedical application potential of biodegradable polymers for anticancer drug delivery
    (Elsevier, 2022) Jain, Ankit
    The major anticancer drugs used for cancer therapy show nonspecificity, wide biodistribution, a short half-life, a low concentration in tumor tissue, and systemic toxicity. The biodegradable polymer can be used as an approach that acts as a drug carrier, offering a targeted drug delivery and increasing the drug payload to the tumor tissues and cells. It also enhances biocompatibility, provides prolonged release of the drug allowing controlled and sustained release, and minimizes systemic toxicity. This chapter focuses on targeted drug delivery through a stimuli-responsive drug carrier that releases its payload at the specified site and on demand in response to an external stimulus. It also emphasizes various applications of biodegradable polymers in breast cancer, lung cancer, colon cancer, and uterine cancer with special emphasis on theranostic applications.
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    Theranostic nanocarriers for cancer applications
    (CRC Press, 2024) Jain, Ankit
    Cancer is one of the deadly diseases with serious health concerns that needed novel therapeutic solutions. For an effective and successful treatment approach, upgraded and advanced diagnostics as well as therapeutic techniques are required. Currently, research and development in this area are in great demand in nanoscience and nanotechnology. They promise to offer innovative and more effective approaches to cancer for its early diagnosis, imaging, and therapy. An emerging and growing trend in this direction is theranostics. It deals with both the diagnosis and therapeutic approach to cancers conjointly. Its prime objectives are to eliminate multi-step processes and reduce delays in cancer treatment. It offers many advantages, such as better-quality diagnosis, cancer-specific drug delivery, and minimization of toxic effects to healthy tissues. Many theranostic nanocarriers like nanoparticles, quantum dots, carbon nanotubes, nanofibers, nanoshells, liposomes, dendrimers, and micelles can be used efficiently for the effective treatment of cancer. This chapter examines several theranostic nanocarriers and their applications for effective cancer treatment.
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    Navigating liver cancer: precision targeting for enhanced treatment outcomes
    (Springer, 2025-01) Jain, Ankit
    Cancer treatments such as surgery and chemotherapy have several limitations, including ineffectiveness against large or persistent tumors, high relapse rates, drug toxicity, and non-specificity of therapy. Researchers are exploring advanced strategies for treating this life-threatening disease to address these challenges. One promising approach is targeted drug delivery using prodrugs or surface modification with receptor-specific moieties for active or passive targeting. While various drug delivery systems have shown potential for reaching hepatic cells, nano-carriers offer significant size, distribution, and targetability advantages. Engineered nanocarriers can be customized to achieve effective and safe targeting of tumors by manipulating physical characteristics such as particle size or attaching receptor-specific ligands. This method is particularly advantageous in treating liver cancer by targeting specific hepatocyte receptors and enzymatic pathways for both passive and active therapeutic strategies. It highlights the epidemiology of liver cancer and provides an in-depth analysis of the various targeting approaches, including prodrugs, liposomes, magneto-liposomes, micelles, glycol-dendrimers, magnetic nanoparticles, chylomicron-based emulsion, and quantum dots surface modification with receptor-specific moieties. The insights from this review can be immensely significant for preclinical and clinical researchers working towards developing effective treatments for liver cancer. By utilizing these novel strategies, we can overcome the limitations of conventional therapies and offer better outcomes for liver cancer patients.