Department of Pharmacy

Permanent URI for this collectionhttp://localhost:4000/handle/123456789/1931

Browse

Filters

2022 - 20258

Settings

Author: search.filters.author.Jain, AnkitSubject: search.filters.subject.Drug delivery

Search Results

Now showing 1 - 8 of 8
  • No Thumbnail Available
    Item
    Lineage of lipid-based endosomal escape in cytosolic delivery to cancer: insight into an unprecedented approach
    (Elsevier, 2025-12) Jain, Ankit
    Endosomal sequestration of lipid-based systems constitutes a significant limitation that undermines the efficient intracellular delivery of therapeutics in cancer treatment. Upon administration, the intracellular fate of drug or gene constructs within lipid-based delivery systems is influenced by various factors, including p-glycoprotein-mediated efflux and lysosomal degradation, which impede sufficient therapeutic agents from reaching their intended targets. This review exhaustively discusses lipids (properties of lipids and role of pKa) and various lipid-based delivery systems facilitating the endosomal escape for cancer treatment. All aspects, such as endosomal sequestration, methods to promote endosomal escape, a mechanistic overview of endosomal escape, detection of endosomal escape, the application potential of lipid-based systems for cancer treatment, and safety of lipid-based systems, were covered in this manuscript. Existing reviews on endosomal escape have accounted for the various mechanisms,. Still, this review paper also furnishes the role of pKa and applications of molecular dynamic simulation in lipid-based drug delivery, and safety concernsof lipid-based nanosystems. This review discussed the influence of material properties on the endosomal escape of therapeutic agents.
  • No Thumbnail Available
    Item
    Environmental stimuli-sensitive chitosan nanocarriers in therapeutics
    (Elsevier, 2022) Jain, Ankit
    Environmental stimuli-sensitive chitosan nanocarriers (SSCNs) have attracted attention in the area of cancer chemotherapy. Chitosan is the most commonly used natural polymer obtained by the deacetylation of chitin. It is a polymer suitable for therapeutic applications owing to its distinctive characteristics including biodegradability, biocompatibility, and nontoxicity. Chitosan consists of amino and hydroxyl groups that can be used chemically to provide stimuli-sensitive characteristics that have promising applications in the field of nanobiomedicines. It is employed for the fabrication of several nanocarriers such as liposomes, nanoparticles, dendrimers, niosomes, micelles, and microparticles. The versatile features of chitosan, such as mucoadhesion, better transfection, in situ gelation, enhancement of absorption, and permeation, have made it a promising candidate for drug delivery. This chapter discusses different types of stimulus-sensitive chitosan nanocarriers (temperature, pH, ultrasound, redox, photo, and magnetic field) along with drug release mechanisms. This strategy is used to deliver therapeutic agent(s) at the target site, which enhances the therapeutic effects with less side effects related to the drug(s). Environmental SSCNs could be a potential approach to future clinical applications
  • No Thumbnail Available
    Item
    A glimpse of biomedical application potential of biodegradable polymers for anticancer drug delivery
    (Elsevier, 2022) Jain, Ankit
    The major anticancer drugs used for cancer therapy show nonspecificity, wide biodistribution, a short half-life, a low concentration in tumor tissue, and systemic toxicity. The biodegradable polymer can be used as an approach that acts as a drug carrier, offering a targeted drug delivery and increasing the drug payload to the tumor tissues and cells. It also enhances biocompatibility, provides prolonged release of the drug allowing controlled and sustained release, and minimizes systemic toxicity. This chapter focuses on targeted drug delivery through a stimuli-responsive drug carrier that releases its payload at the specified site and on demand in response to an external stimulus. It also emphasizes various applications of biodegradable polymers in breast cancer, lung cancer, colon cancer, and uterine cancer with special emphasis on theranostic applications.
  • No Thumbnail Available
    Item
    Advanced hydrogels in drug delivery and wound healing
    (MDPI, 2024-12) Jain, Ankit
  • No Thumbnail Available
    Item
    Theranostic nanocarriers for cancer applications
    (CRC Press, 2024) Jain, Ankit
    Cancer is one of the deadly diseases with serious health concerns that needed novel therapeutic solutions. For an effective and successful treatment approach, upgraded and advanced diagnostics as well as therapeutic techniques are required. Currently, research and development in this area are in great demand in nanoscience and nanotechnology. They promise to offer innovative and more effective approaches to cancer for its early diagnosis, imaging, and therapy. An emerging and growing trend in this direction is theranostics. It deals with both the diagnosis and therapeutic approach to cancers conjointly. Its prime objectives are to eliminate multi-step processes and reduce delays in cancer treatment. It offers many advantages, such as better-quality diagnosis, cancer-specific drug delivery, and minimization of toxic effects to healthy tissues. Many theranostic nanocarriers like nanoparticles, quantum dots, carbon nanotubes, nanofibers, nanoshells, liposomes, dendrimers, and micelles can be used efficiently for the effective treatment of cancer. This chapter examines several theranostic nanocarriers and their applications for effective cancer treatment.
  • No Thumbnail Available
    Item
    DES-igning the future of drug delivery: A journey from fundamentals to drug delivery applications
    (Elsevier, 2024-04) Jain, Ankit
    The pharmaceutical industry relies extensively on solvents for various purposes, including synthesis, crystallization, purification, solubilization, and developing drug delivery systems. Deep Eutectic Solvents (DES) represent an advanced class of solvents characterized by their unique attributes, including high polarity, negligible volatility, exceptional thermal resilience, robust ionic conductivity, low melting point, and structural flexibility. Unique physicochemical properties of DES, including density, conductivity, surface tension, and polarity, are intricately connected, and complex behavior in an aqueous environment presents challenges and opportunities across various applications and demands a holistic understanding. In this comprehensive review, we have encapsulated all facets of DES, encompassing diverse preparation methods, detailed exploration of physicochemical properties, solubilization of various Active Pharmaceutical Ingredients (APIs), and elucidation of different delivery routes. DES can be categorized into five primary types based on their compositions and delves into emerging classes like Natural DES (NADES) and Therapeutic DES (THEDES). The introduction of DES derivatives (DESD), Hydrophobic DES (HDES) and Magnetic DES (MDES) further broaden the scope of DES applications. DESs have showcased remarkable potential in drug delivery by enhancing the permeation of active ingredients across and into the skin by acting as promoters of absorption over the skin's outer layers. While we have explored the applications of DES across various routes of administration in this article, the primary focus lies on its potential for topical delivery. Their application in drug delivery through nasal, ocular, and buccal routes holds promise for enhancing therapeutic outcomes. Nevertheless, the toxicity of DESs remains a subject of scrutiny, necessitating systematic evaluation in both in vitro and in vivo studies. Furthermore, this article provides insights into the challenges and offers a glimpse into the future perspectives within the realm of DES. Despite the promising potential of DES in drug delivery, there are currently no approved products based on DES in the market. Their unique properties, coupled with ongoing research and development endeavors, hold the potential to revolutionize drug formulation and delivery.
  • No Thumbnail Available
    Item
    An insight into pharmaceutical challenges with ionic liquids: where do we stand in transdermal delivery?
    (Frontiers, 2024-08) Jain, Ankit
    Ionic liquids (ILs) represent an exciting and promising solution for advancing drug delivery platforms. Their unique properties, including broad chemical diversity, adaptable structures, and exceptional thermal stability, make them ideal candidates for overcoming challenges in transdermal drug delivery. Despite encountering obstacles such as side reactions, impurity effects, biocompatibility concerns, and stability issues, ILs offer substantial potential in enhancing drug solubility, navigating physiological barriers, and improving particle stability. To propel the use of IL-based drug delivery in pharmaceutical innovation, it is imperative to devise new strategies and solvents that can amplify drug effectiveness, facilitate drug delivery to cells at the molecular level, and ensure compatibility with the human body. This review introduces innovative methods to effectively address the challenges associated with transdermal drug delivery, presenting progressive approaches to significantly improve the efficacy of this drug delivery system.
  • No Thumbnail Available
    Item
    A comprehensive review of challenges and advances in exosome-based drug delivery systems
    (RSC, 2024-10) Jain, Ankit
    Exosomes or so-called natural nanoparticles have recently shown enormous potential for targeted drug delivery systems. Several studies have reported that exosomes as advanced drug delivery platforms offer efficient targeting of chemotherapeutics compared to individual polymeric nanoparticles or liposomes. Taking structural constituents of exosomes, viz., proteins, nucleic acids, and lipids, into consideration, exosomes are the most promising carriers as genetic messengers and for treating genetic deficiencies or tumor progression. Unfortunately, very little attention has been paid to the factors like source, scalability, stability, and validation that contribute to the quality attributes of exosome-based drug products. Some studies suggested that exosomes were stable at around −80 °C, which is impractical for storing pharmaceutical products. Currently, no reports on the shelf-life and in vivo stability of exosome formulations are available. Exosomes are quickly cleared from blood circulation, and their in vivo distribution depends on the source. Considering these challenges, further studies are necessary to address major limitations such as poor drug loading, reduced in vivo stability, a need for robust, economical, and scalable production methods, etc., which may unlock the potential of exosomes in clinical applications. A few reports based on hybrid exosomes involving hybridization between different cell/tumor/macrophage-derived exosomes with synthetic liposomes through membrane fusion have shown to overcome some limitations associated with natural or synthetic exosomes. Yet, sufficient evidence is indispensable to prove their stability and clinical efficacy