Department of Chemistry
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Item Synthesis of bicyclic γ-lactam derivatives by intramolecular carbene insertion and aza-Wittig reaction(J-Global, 2013) Addy, Partha SarathiA comparative study of the various methodologies to construct bicyclic γ-lactams is reported. Thus RhII-catalyzed decomposition of 2-pyrrolidone and pyrrolidine derived diazomalonates were attempted to synthesize fused γ-lactams. Spectral evidences revealed the formation of diastereomeric alcohols instead of desired C-H or N-H insertion products, indicating significant conformational bias towards insertion process. On the other hand, the method involving the N-H insertion onto the lactam nitrogen of 2-pyrrolidone ring was successful. Intramolecular aza-Wittig reaction was also successfully explored to construct bicyclic γ-lactam scaffolds. All the bicyclic analogues showed weak antibacterial activity against S. aureus and E. coli.Item Synthesis of highly efficient pH-sensitive DNA cleaving aminomethyl N-substituted cyclic enediyne and its L-lysine conjugate(Elsiever, 2013-02-20) Addy, Partha SarathiTwo 10-membered benzo-fused N-substituted cyclic enediynes, one an amino methyl and the other, a C-lysine conjugated derivative 2 and 3, respectively were synthesized (as a 1.2:1 mixture of regioisomers) and their DNA-cleavage efficiency studied. Both the compounds showed much better DNA-cleavage profile than that of the parent unsubstituted enediyne 1. The lysine conjugate 3 showed an efficient pH dependent cleavage to the extent of ∼50% of linear DNA formation under ambient conditions.Item ChemInform Abstract: Design and Synthesis of Azobenzene Template Based Sulfonamide for Capture of HCAII: Dependence of Efficiency on E—Z Geometry(Wiley, 2014-08-28) Addy, Partha Sarathi