Department of Chemistry

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Author: search.filters.author.Kumar, DalipSubject: search.filters.subject.Microwave irradiation

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Now showing 1 - 7 of 7
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    Solid State Oxidation of Benzoins on Alumina-Supported Copper(II) Sulfate under Microwave Irradiation
    (RSC, 1998) Kumar, Dalip
    Benzoins are rapidly oxidised to benzils in high yields by the solid reagent system copper(II) sulfate–alumina, under the influence of microwaves.
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    Solventless Regeneration of Ketones from Thioketones using Clay Supported Nitrate Salts and Microwave Irradiation
    (Taylor & Francis, 1999) Kumar, Dalip
    Thioketones are readily converted into the corresponding ketones under solvent-free conditions using clayfen or clayan in a process that is accelerated by microwave irradiation.
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    Sulfated Zirconia-catalyzed One-pot Benign Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones under Microwave Irradiation
    (CSJ, 2006) Kumar, Dalip
    Sulfated zirconia has been demonstrated as an efficient catalyst for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones under microwave irradiation and conventional heating. The solid acid catalyst is found to be highly active for the one-pot condensation of aldehydes, urea and β-dicarbonyl compound, affording variety of 3,4-dihydropyrimidin-2(1H)-ones in excellent yields with high purity. The low cost catalyst has exhibited remarkable reactivity and recycled without any significant loss of activity.
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    Ionic liquid catalyzed expeditious synthesis of 2-aryl-2,3-dihydroquinolin-4(1H)-ones and 2-aryl-2,3-dihydro-4H-chromen-4-ones under microwave irradiation
    (Wiley, 2009-06-19) Kumar, Dalip
    A facile and convenient synthesis of 2-aryl-2,3-dihydroquinolin-4(1H)-one and 2-aryl-2,3-dihydro-4H-chromen-4-one has been described using ionic liquid catalyzed intramolecular cyclization of the corresponding 2′-aminochalcones and 2′-hydroxychalcones, respectively. The rapid and fairly general protocol affords product in good yield. Ionic liquid, 1-butyl-3-methylimidazolium tetrafluoroborate, was recovered and reused without loosing its efficiency.
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    A Metal-Free and Microwave-Assisted Efficient Synthesis of Diaryl Sulfones
    (Thieme, 2013) Kumar, Dalip
    An efficient and general protocol for the synthesis of diaryl sulfones via the metal-free coupling of readily available diaryliodonium salts and arenesulfinates in PEG-400 under microwave irradiation has been developed. Utilizing this metal-free and eco-friendly protocol, we have prepared various diaryl sulfones in high yields and shorter reaction times under mild conditions. Furthermore, the coupling of diaryliodonium with arenesulfinate salts with and without copper iodide provides a convenient access to various diaryl sulfones with high selectivity.
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    Ionic liquid catalyzed expeditious synthesis of 2-aryl-2,3-dihydroquinolin-4(1H)-ones and 2-aryl-2,3-dihydro-4H-chromen-4-ones under microwave irradiation
    (Wiley, 2009-06-19) Kumar, Anil; Kumar, Dalip
    A facile and convenient synthesis of 2-aryl-2,3-dihydroquinolin-4(1H)-one and 2-aryl-2,3-dihydro-4H-chromen-4-one has been described using ionic liquid catalyzed intramolecular cyclization of the corresponding 2′-aminochalcones and 2′-hydroxychalcones, respectively. The rapid and fairly general protocol affords product in good yield. Ionic liquid, 1-butyl-3-methylimidazolium tetrafluoroborate, was recovered and reused without loosing its efficiency
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    A Facile and Microwave-assisted Rapid Synthesis of 2-Arylamino-4-(3'-indolyl)- thiazoles as Apoptosis Inducing Cytotoxic Agents
    (Bentham Science, 2017) Kumar, Anil; Kumar, Dalip
    The clinical success of the chemotherapeutic drugs is restricted by the nonspecific toxicity-related adverse side effects. The diverse implication of indoles and thiazoles in medicinal chemistry prompted us to develop a new series of novel 2-aryl-amino-4-(3′-indolyl)thiazoles as more effective and less toxic anti-cancer compounds. Method and Results: One-pot microwave-assisted rapid and high yielding synthesis of 2-arylamino-4-(3′- indolyl)thiazoles involved the reaction of easily available α-tosyloxy-ketones with N-arylthioureas in polyethylene glycol-400 (PEG-400). In vitro cytotoxicity study of 2-arylamino-4-(3′-indolyl)thiazoles against a panel of human cancer cell lines by MTT assay revealed IC50 values in the low micromolar range. Of the fifteen synthesized arylaminothiazoles, compounds 17b, 17d, 17g and 17il showed significant anti-proliferative activity against the selected cancer cell lines with IC50 < 10 μM. The compound 17b was identified as the most potent ligand of the series, which exhibited good cytotoxic activity against MCF-7 breast cancer cells with an IC50 value of 1.86 μM but minimal toxicity on normal human cells. Investigation of the underlying mechanism by flow cytometry indicated that 17b induced ROS-mediated apoptosis in MCF-7 cells in a dose-dependent manner as supported by upregulation of Bax and caspase-3 and down-regulation of Bcl-2 (by Western blot).