Department of Chemistry
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Item The synthesis of amino acid derived glycoconjugates and the investigation of their anti-inflammatory and analgesic properties(2014) Sah, Ajay KumarA series of 4,6-O-ethylidene-β-D-glucopyranosylamine derived glycoconjugates containing amino- and aromatic acids have been synthesized. All these molecules have been tested for their anti-inflammatory and analgesic activity on Wistar rat and Swiss Albino mice respectively. The anti-inflammatory studies were explored using a carrageenan induced paw oedema model while an acetic acid induced writhing model was adapted for the analgesic studies. All of the compounds exhibited anti-inflammatory and analgesic activity in the range of 63–84% and 86–94% respectively.Item Synthesis and Characterization of Glucose Derived Dioxo-molybdenum (VI) Complexes and Their Application in Sulphide Oxidation(Springer, 2015-03) Sah, Ajay KumarThree new molybdenum (VI) complexes of 4,6- O-ethylidene-b-D-glucopyranosylamine derived ligands has been synthesized and the same has been used in the oxidation of thioanisole along with an earlier reported analogous complex. A selective oxidation of thioanisole to methyl phenyl sulphoxide in high yield is achieved using 1:1 mixture of thioanisole and urea hydrogen peroxide (UHP) in ethanol. A longer reaction time or excess of UHP, leads to the formation of the corresponding sulphone, which was confirmed using HPLC and NMR measurements. Graphical Abstract The oxidation of thioanisole into corresponding sulphoxide and sulphone has been explored using dioxo-molybdenum (VI) complexes of 4,6-O-ethyli- dene-b-D-glucopyranosylamine derived Schiff base ligand.Item Synthesis of Mefenamic Acid Containing N-Glycoconjugates and Their Evaluation as Human COX-2 Enzyme Inhibitor(Wiley, 2020-02-17) Sah, Ajay KumarA series of d-glucose derived N-glycopeptides containing mefenamic acid have been synthesised and in vitro evaluation of all these molecules have been performed as COX-2 (human) enzyme inhibitor using Enzymes Immuno Assay kit. These studies were further supported by docking experiments on human COX-2 enzyme (PDB ID: 5IKR). All the compounds exhibited a fair amount of COX-2 enzyme inhibition during both the modes of study and tryptophan derivative showed the best activity. Acute toxicity (LD50) in rat has also been evaluated using General Unrestricted Structure-Activity Relationships (GUSAR) software, where acute oral toxicity for most of the molecules was found to be less than the pure mefenamic acid.