Department of Biological Sciences
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Item Antimicrobial Haplindole Alkaloids as Chemical Marker for Rapid Identification of Stigonematales (Cyanobacteria)(Taylor & Francis, 2020-12) Verma, Sanjay KumarAntimicrobial Hapalindole alkaloids have been identified in the order Stigonematales. Being exclusively present in a few members of this order, they can easily serve as a good chemical marker for their identification. In the present experiment, some locally isolated cyanobacterial strains were identified on the basis of these chemical compounds. Cyanobacterial strains were isolated from natural samples through standard techniques. Their antimicrobial activity was tested against various fungal and bacterial strains, which include: Psuedomonas syringe, Escherichia coli, Bacillus cereus, Pseudomonas putida, Salmonella sp., Fusarium oxysporum, Cercospora canescens and Colletotricum dematium. Of the several natural isolates, two strains showed strong antimicrobial activity against most of the tested microorganisms. Isolates showing antimicrobial activity were further subjected to DART-MS analysis to identify the chemical compounds. Mass spectra revealed the presence of a range of hapalindole alkaloids, which were confirmed through their exact mass measurement, elemental composition determination, and fragment ion generation in the DART source. Quantitative analysis was conducted by measuring relative abundance.Item Curcumin reduces the antimicrobial activity of ciprofloxacin against Salmonella Typhimurium and Salmonella Typhi(OUP, 2012-10-15) Marathe, SandhyaTyphoidal and non-typhoidal infection by Salmonella is a serious threat to human health. Ciprofloxacin is the last drug of choice to clear the infection. Ciprofloxacin, a gyrase inhibitor, kills bacteria by inducing chromosome fragmentation, SOS response and reactive oxygen species (ROS) in the bacterial cell. Curcumin, an active ingredient from turmeric, is a major dietary molecule among Asians and possesses medicinal properties. Our research aimed at investigating whether curcumin modulates the action of ciprofloxacin.Item ChemInform Abstract: Novel Grinding Synthesis of Pyranopyrazole Analogues and Their Evaluation as Antimicrobial Agents.(Wiley, 2016) Jha, Prabhat N.; Shukla, ParitoshCompounds are prepared and screened for their antibacterial and antifungal activities