Department of Biological Sciences

Permanent URI for this collectionhttp://localhost:4000/handle/123456789/1922

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Subject: search.filters.subject.Green chemistry

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    Greener alternatives for synthesis of isoquinoline and its derivatives: a comparative review of eco-compatible synthetic routes
    (RSC, 2025) Deepa, P.R.; Murugesan, Sankaranarayanan
    Isoquinoline derivatives, a prominent class of nitrogen-containing heterocycles, serve a pivotal role in medicinal chemistry due to their broad spectrum of bioactivities. While traditional synthetic routes for these scaffolds are well-established, conventional methods often rely on transition-metal catalysts, harsh conditions, expensive reagents, and toxic solvents, raising environmental and economic concerns. In response to the pressing demand for sustainable practices, this review underscores the integration of green chemistry principles into modern synthetic design, offering environmentally acceptable methods for accessing isoquinoline frameworks. Despite extensive research on isoquinoline synthesis and its therapeutic relevance, a dedicated analysis of sustainable methodologies remains absent. This work bridges that gap by critically evaluating recent innovations in green synthesis, including the use of benign solvents, recyclable catalytic systems, atom-economical reactions, and energy-efficient processes.
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    Green Synthesis, in-vitro Antimicrobial Evaluation, Docking, and SAR Studies of Potent Quinoline-4-Carboxylic Acids
    (Bentham Science, 2019) Jha, Prabhat N.; Murugesan, Sankaranarayanan; Shukla, Paritosh
    The paper describes the synthesis of quinoline-4-carboxylic acid derivatives employing completely green methods such as the use of water as solvent and of microwave irradiation for heating. The prepared molecules were examined for bactericidal and antifungal behavior and two of the tested compounds showed reasonably good antimicrobial activity. The biological activity results were further corroborated by fluorescence microscopy and by evaluating their time-dependent bactericidal behavior. Two of the most potent compounds were then subjected to docking against DNA gyrase protein (PDB ID: 2XCT) showing possible interactions responsible for the potency of these compounds. Also, an SAR analysis was proposed based on the results obtained