Department of Chemistry

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    Synthesis of Novel Ligands Containing Saccharide and Amino Acids Reactivities of the Resultant Molecules
    (BITS Pilani, 2013) Soni, Kiran
    This thesis contains the synthesis characterization and reactivities of Dglucose derived newlineglycoconjugates Reactivities include the application of free as well as metal ion bound newlineglycoconjugates in vivo and in vitro system newlineThe first chapter deals with the introduction to carbohydrates its classifications and role newlinein biological system This chapter also deals with the metallochemistry aspects of newlinecarbohydrate derived molecules newlineDetails of materials and method used in this thesis are summarized in second chapter newlineThird chapter illustrates the synthesis and characterization of 46Oethylideneand#946;Dglucopyranosylamine newlinederived glycoconjugates C1C9 The molecular structure of one of newlinethe glycoconjugtes N2hydroxybenzoylLalanyl46Oethylideneand#946;Dglucopyranosylamine newlineC1 has been established using single crystal Xray diffraction newlinemethod and the details are also presented in this chapter newlineVarious reactivities of N2hydroxybenzoylLalanyl46Oethylideneand#946;Dglucopyranosylamine newlineand analogous compounds have been presented in three subsections newline41 42 and 43 of chapter four Section 41 deals with the metallochemistry of the newlinecompound C1 while its interactions with amino acids and one of the proteins BSA is newlinesummarized in 42 C1 interacts with the copper acetate in the various metal salts newlinesolutions Same molecule selectively recognizes the tryptophan in free as well as in newlineprotein bound state Section 43 contains the details of analgesic and antiinflammatory newlineactivities of N2hydroxybenzoylLalanyl46Oethylideneand#946;Dglucopyranosylamine newlineand its analogous compounds All the mentioned compounds behaves as good analgesic newlineand antiinflammatory agents newlineSynthesis characterization and reactivities of Lalanyl46Oethylideneand#946;Dglucopyranosylamine newlinederived schiff bases K1K3 is presented in two subsections 51 newlineand 52 of chapter five Section 51 deals with the synthesis characterization and newlinemetallochemistry of N2hydroxybenzylLalanyl46Oethylideneand#946;Dglucopyranosylamine newlineK1 while its interactions with amino acids are summarized in 52 newlineK1 molecule interacts with MnII NiII CuII CoII and Zn II acetates
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    Synthesis and Photocytotoxicity Studies of Some Novel Porphyrin Heterocycles
    (BITS Pilani, 2013) Mishra, Bhupendra Ashok
    Porphyrinoids have found promising applications as photosensitizers in photodynamic therapy and newlinephotodynamic imaging due to their unique absorption and emission properties in visible region 400800 nm newlineAlso their ability to absorb light and transfer its energy to molecular oxygen to produce reactive oxygen newlinespecies ROS such as singlet oxygen and superoxide radicals which initiate a series of complex chemical and newlinebiological events that ultimately leads to cell death Porphyrins and metalloporphyrins are also ideal model newlinecompounds for studying light harvesting energy and electron transfer and redox catalysis This thesis newlinedescribes the synthesis absorptionemission and photocytotoxicity properties of some novel porphyrin newlineconjugates and porphyrinbased heterocycles newlineThe thesis entitled Synthesis and biological Studies of some novel porphyrins and their conjugates is divided newlineinto four chapters The first chapter Introduction provides some insight about natural occurrence of newlineporphyrins their nomenclature and photophysical properties A detailed review of classical synthetic routes to newlinethe most recent improvements to achieve simple as well as complex porphyrin systems has been provided newlineParticularly porphyrinbased photosensitizers currently in market and several others in clinical trials have also newlinebeen elaborated along with their mechanism of action newlineThe second chapter unveils design synthesis and photocytotoxicity studies of some cationic porphyrin newlineconjugates The work embodied in this chapter has been divided into four parts Part A Part B Part C and Part newlineD Part A reports an iodineIIImediated facile synthesis of 4and#8242;cyanophenylporphyrins from readily newlineavailable porphyrin thioamides Two novel cationic cyanoporphyrins displayed efficient photonuclease activity newline1 and#956;M and their absorption and emission studies.