BITS Faculty Publications

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Author: search.filters.author.Khungar, BhartiSubject: search.filters.subject.Biology

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    Pyridinium-based schiff-base fluorescent chemosensor for sequential detection of al3+ ions and tnp: applications in cell imaging and latent fingerprint visualization
    (Wiley, 2024-12) Jha, Prabhat Nath; Khungar, Bharti
    A fluorescent pyridinium-based chemosensor (E)-1-(2-(3-hydroxy-4-((pyridin-2-ylimino) methyl) phenoxy) ethyl) pyridin-1-ium bromide (BzPySB) was synthesized and characterized using various spectroscopic techniques. The chemosensing potential of BzPySB was explored using UV-vis and fluorescence spectroscopy in the aqueous medium. The turn-on fluorescence behavior was observed for BzPySB in the presence of Al3+, while other metal ions were non-responsive. The B−H and Job′s plot confirmed the 1 : 1 stoichiometric ratio of the BzPySB and Al3+. The in situ generated complex BzPySB-Al3+ offered selectivity toward TNP via fluorescence turn-off phenomena with high Ksv and LOD values. The “off-on-off” sensing mechanism was elucidated through 1H NMR, mass spectrometry, and DFT calculations. The probe also detected Al3+ in plant and MCF-7 cells, highlighting its potential in biological systems. Moreover, BzPySB exhibited solid-state luminescent properties credited to weak π-π interaction, leading to its successful application in the visualization of latent fingerprints.
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    Synthesis, characterization and microbiocidal studies of novel ionic liquid tagged Schiff bases
    (Elsiever, 2012-08) Khungar, Bharti; Kumar, Anil; Panwar, Jitendra
    The synthesis of novel imidazolium ionic liquid, tagged Schiff, has been described. The synthesis was achieved in three steps from 2,4-dihydroxybenzaldehyde by selective alkylation with 1,3-dibromopropane, followed by reaction with 1-methylimidazole and Schiff base formation with aromatic amines. The compounds were evaluated for antibacterial and antifungal activities. The ionic liquid tagged Schiff base 4a showed the inhibition of both Gram positive and Gram negative bacteria. It also showed broad spectrum antifungal activity against all four tested fungi; however, 4f showed highest antifungal activity against A. niger.
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    Synthesis, characterization and applications of imidazolium ionic liquid-tagged zinc(II) complex
    (Elsiever, 2018) Khungar, Bharti; Nehra, Pankaj; Sivasubramanian, S.C.; Jha, Prabhat N.
    A multi-functional zinc(II) complex of an imidazolium ionic liquid-tagged ligand was synthesized and characterized. The DSC and TGA analysis showed the thermal stability of the complex. The complex showed emission λmax at 368–467 nm with quantum yields up to 0.06. The time-resolved fluorescence study revealed enhancement in lifetime on complexation with zinc(II) ion indicating conformational rigidity. The complex showed good DNA cleavage, antifungal and antibacterial activities against Gram +ve and Gram −ve bacteria. The complex was found to be a good catalyst for the reaction of aromatic aldehydes and indole substrates in water to synthesize bis(indolyl)methanes.