BITS Faculty Publications
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Item Copper-catalyzed synthesis of quinoline derivatives via tandem Knoevenagel condensation, amination and cyclization(RSC, 2016) Kumar, Anil; Kumar, DalipA novel regioselective synthesis of 2-aminoquinolines and 2-arylquinoline-3-carbonitriles is described via copper-mediated tandem reaction. Formation of substituted quinolines involves Knoevenagel condensation of ortho-bromobenzaldehyde with active methylene nitriles followed by copper-catalyzed reductive amination and intramolecular cyclization.Item A Facile Synthesis of Quinazolin-4(3H)-ones via Copper-Catalyzed One-Pot, Three-Component Tandem Reaction(Wiley, 2017-09-13) Kumar, Anil; Kumar, DalipA simple and convenient one-pot, three-component tandem reaction has been developed for the synthesis of substituted quinazolin-4(3H)-ones using CuI/L-proline as catalytic system. A series of 35 quinazolin-4(3H)-ones was synthesized in good to high yield. The method involves copper-catalyzed double C−N coupling, reductive amination, condensation, cyclization and aerobic oxidation. Good functional group tolerance, mild reaction condition, readily available starting materials and user friendly procedure makes this protocol practically good and attractive method for the synthesis of quinazolin-4(3H)-ones.Item Copper-Catalyzed Tandem Imine Formation, Sonogashira Coupling and Intramolecular Hydroamination: A Facile Synthesis of 3-Aryl-γ−carbolines(Wiley, 2021-11-25) Kumar, Anil; Kumar, DalipA one-pot, atom-economical multicomponent reaction of 2-bromoindole-3-carbaldehydes, alkynes and ammonia was developed in the presence of copper catalyst for the synthesis of a series of 3-aryl-γ−carboline derivatives in good to high yields. The developed reaction involved formation of imine followed by copper-catalyzed directed Sonogashira coupling and intramolecular hydroamination sequence of reactions. This multicomponent approach features mild reaction conditions and good functional group tolerance to access variety of 3-aryl γ-carbolines.