BITS Faculty Publications
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Item Molecular docking and in silico adme(t) evaluation of selective phytochemical inhibitors of vegf2 target for the treatment of diabetic retinopathy(Bentham Science, 2024-10) Murugesan, SankaranarayananDiabetic retinopathy (DR) is the leading cause of vision loss in diabetic patients. Currently, the treatment involves the use of glucocorticoids or a VEGF antagonist, which are “off-label” at present. However, the conventional method of drug discovery and development is a time-consuming process that requires more than a decade of meticulous research and huge financial support. While there are a few effective small organic molecules against DR that were identified many years ago, nutraceuticals - naturally available functional foods containing vitamins, antioxidants, minerals, fatty acids, and amino acids - can also help delay the progression of some diseases.Item Identification of potential inhibitors from medicinal plant-based phytochemicals for the influential c4 target of diabetic retinopathy by molecular docking studies(Bentham Science, 2024-08) Murugesan, SankaranarayananDiabetic retinopathy is the major cause of vision failure in diabetic patients, and the current treatment involves the practice of glucocorticoids or VEGF antagonists that are “off-label”. A few small organic molecules against DR were discovered many years ago. Nutraceuticals are naturally available functional foods that endorse different health benefits, including vitamins, antioxidants, minerals, fatty acids, and amino acids that can defer the development of some diseases.