BITS Faculty Publications

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Author: search.filters.author.Sah, Ajay KumarSubject: search.filters.subject.Amino acids

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    The synthesis of amino acid derived glycoconjugates and the investigation of their anti-inflammatory and analgesic properties
    (2014) Sah, Ajay Kumar
    A series of 4,6-O-ethylidene-β-D-glucopyranosylamine derived glycoconjugates containing amino- and aromatic acids have been synthesized. All these molecules have been tested for their anti-inflammatory and analgesic activity on Wistar rat and Swiss Albino mice respectively. The anti-inflammatory studies were explored using a carrageenan induced paw oedema model while an acetic acid induced writhing model was adapted for the analgesic studies. All of the compounds exhibited anti-inflammatory and analgesic activity in the range of 63–84% and 86–94% respectively.
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    N-Glycoconjugates: Selective colorimetric chemosensors for aspartic acid and cysteine
    (Elsiever, 2021-10-05) Sah, Ajay Kumar
    Selective recognition of naturally occurring amino acids have been explored using five glycopeptide-based receptors with the help of UV-visible and 1H NMR spectroscopy, while structures of two glycopeptides have been established via single crystal X-ray diffraction studies. The receptors containing alanine, valine, isoleucine and methionine moieties interact selectively with aspartic acid, while phenylalanine derivative with cysteine.
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    Synthesis, evaluation and molecular docking studies of amino acid derived N-glycoconjugates as antibacterial agents
    (Elsiever, 2015-12) Jha, Prabhat N.; Sah, Ajay Kumar; Murugesan, Sankaranarayanan
    Six amino acid derived N-glycoconjugates of d-glucose were synthesized, characterized and tested for antibacterial activity against G(+)ve (Bacillus cereus) as well as G(−)ve (Escherichia coli and Klebsiella pneumoniae) bacterial strains. All the tested compounds exhibited moderate to good antibacterial activity against these bacterial strains. The results were compared with the antibacterial activity of standard drug Chloramphenicol, where results of A5 (Tryptophan derived glycoconjugates) against E. coli and A4 (Isoleucine derived glycoconjugates) against K. pneumoniae bacterial strains are comparable with the standard drug molecule. In silico docking studies were also performed in order to understand the mode of action and binding interactions of these molecules. The docking studies revealed that, occupation of compound A5 at the ATP binding site of subunit GyrB (DNA gyrase, PDB ID: 3TTZ) via hydrophobic and hydrogen bonding interactions may be the reason for its significant in vitro antibacterial activity.