BITS Faculty Publications

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    The Role of TRPV1 in Acquired Diseases: Therapeutic Potential of TRPV1 Modulators
    (Elsevier, 2015) Khare, Pragyanshu
    The transient receptor potential vanilloid 1 (TRPV1) is a nonselective cation channel with high calcium permeability that has been studied extensively since its identification and characterization in 1997. Its involvement in different modalities of pain has been well documented, which has resulted in the development of novel strategies for the treatment of pain. However, TRPV1 is also involved in a plethora of other physiological and pathophysiological functions related to urinary, cardiovascular, gastrointestinal, respiratory, and central nervous systems. Here, we summarize the recent developments of the role of TRPV1 in acquired diseases and review the current perspective of TRPV1 agonist and antagonist as potential drugs for therapeutic intervention.
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    Emerging trends in microneedle-based drug delivery strategies for the treatment of rheumatoid arthritis
    (Taylor & Francis, 2022-04) Singhvi, Gautam
    The current drug therapies for treating rheumatoid arthritis (RA) include nonsteroidal anti-inflammatory drugs, disease-modifying antirheumatic drugs, or biological products designed to mitigate the symptoms of the disease. These therapies with conventional delivery systems possess limitations such as lack of selectivity and adverse effects in the extra-articular tissues. Microneedles-based transdermal drug delivery gained huge attention that can overcome the limitations associated with conventional preparations.
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    Folic Acid in Pain: An Epigenetic Link
    (Elsevier, 2017) Gaikwad, Anil Bhanudas
    Pain, due to its variability and lack of clear definition, forms one of the biggest challenges being faced by the physicians globally. The current therapeutic interventions being used to treat or reduce pain seem to be insufficient to solve the problem. Although the mechanisms underlying pain and associated with “killing pain” have been in limelight since time immemorial, the exact mechanisms have not yet been delineated. The genetic and epigenetic basis of pain and its treatment are emerging as potential answers to the unsolved queries associated with pain. Folic acid (vitamin B9) has been reported to show a potential role in treatment of various types of pains including joint pain (rheumatoid arthritis), myofascial pain, and cancer-associated pain. This pharmacological property displayed by folic acid could rightly be linked to the epigenetic alterations associated with folic acid administration. This review attempts to link the analgesic effect of folic acid with its deoxyribonucleic acid (DNA) methylation property (a major epigenetic alteration), which may help us understand the molecular basis of analgesic effect of folic acid in a more appropriate manner.
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    Evaluation of Anti-depressant and Analgesic- Like Activity of Ondansetron in Rodents Model of Co-morbid Pain and Depression
    (IJPER, 2015-02) Mahesh, R.; Yadav, Sushil
    Although a clinical connection between pain and depression has long been recognized, how these two conditions interact remains unclear. Here we report the comorbidity of pain and depression-like behavior. The antidepressant and analgesic like activity of Ondansetron (OND, 0.25-2mg/kg) were investigated in animal models of acute depression (forced swim test ) and pain ( tail flick test) , existence of co-morbidity of pain and depression was simulated in surgical models in rats like olfactory bulbectomy (OBX) model of chronic depression and chronic constrictive injury (CCI) of chronic pain conditions. Acute administration of OND (0.5-2mg/kg i.p) significantly reduced the duration of immobility in mice in FST and increased the time latency in tail flick test. Behavioural anomalies shown by OBX rats in open field test was significantly reversed by OND (1-2 mg/kg p.o) but OBX rats failed to show the any kind of nociception. Further OND successfully reversed pain in CCI rats. In addition to reversal of pain, OND (1-2mg/kg p.o) significantly reduced the hyperactivity exhibited by CCI rats in open field test suggesting the effect of OND in co-morbid pain and depression. OND exhibited significant antidepressant and analgesic like effect as indicated by its ability to reduce swim stress induced immobility and reduction in writhing. The present study showed that OND has equal efficacy in comorbid pain and depression-like behavioural mediated through serotonergic system.
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    Evaluation of Anti-depressant and Analgesic- Like Activity of Ondansetron in Rodents Model of Co-morbid Pain and Depression
    (IJPER, 2015-02) Mahesh, R.; Yadav, Sushil
    Although a clinical connection between pain and depression has long been recognized, how these two conditions interact remains unclear. Here we report the comorbidity of pain and depression-like behavior. The antidepressant and analgesic like activity of Ondansetron (OND, 0.25-2mg/kg) were investigated in animal models of acute depression (forced swim test ) and pain ( tail flick test) , existence of co-morbidity of pain and depression was simulated in surgical models in rats like olfactory bulbectomy (OBX) model of chronic depression and chronic constrictive injury (CCI) of chronic pain conditions. Acute administration of OND (0.5-2mg/kg i.p) significantly reduced the duration of immobility in mice in FST and increased the time latency in tail flick test. Behavioural anomalies shown by OBX rats in open field test was significantly reversed by OND (1-2 mg/kg p.o) but OBX rats failed to show the any kind of nociception. Further OND successfully reversed pain in CCI rats. In addition to reversal of pain, OND (1-2mg/kg p.o) significantly reduced the hyperactivity exhibited by CCI rats in open field test suggesting the effect of OND in co-morbid pain and depression. OND exhibited significant antidepressant and analgesic like effect as indicated by its ability to reduce swim stress induced immobility and reduction in writhing. The present study showed that OND has equal efficacy in comorbid pain and depression-like behavioural mediated through serotonergic system.