Ball-Milling-Enabled Zn(OTf)2-Catalyzed Friedel–Crafts Hydroxyalkylation of Imidazo[1,2-a]pyridines and Indoles

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dc.contributor.authorKumar, Anil
dc.date.accessioned2024-09-10T09:23:25Z
dc.date.available2024-09-10T09:23:25Z
dc.date.issued2023-02
dc.description.abstractA facile and efficient synthetic method for the construction of C3-hydroxyalkylated imidazo[1,2-a]pyridines and indoles by a Zn(OTf)2-catalyzed Friedel–Crafts hydroxyalkylation of imidazo[1,2-a]pyridines and indoles with carbonyl compounds under mechanochemical conditions is reported. Good product selectivity, shorter reaction time, ambient reaction temperature, tolerance of a wide range of functional groups, broad substrate scope, moderate to good yield of products, and scalability are the salient features of the developed methodology.en_US
dc.identifier.urihttps://pubs.acs.org/doi/10.1021/acs.joc.2c02719
dc.identifier.urihttps://dspace.bits-pilani.ac.in/xmlui/handle/123456789/15508
dc.language.isoenen_US
dc.publisherACSen_US
dc.subjectChemistryen_US
dc.subjectChemical Reactionsen_US
dc.subjectEthyl groupsen_US
dc.subjectIndolesen_US
dc.subjectPyridinesen_US
dc.subjectSilica Nanoparticles (SiNP)en_US
dc.titleBall-Milling-Enabled Zn(OTf)2-Catalyzed Friedel–Crafts Hydroxyalkylation of Imidazo[1,2-a]pyridines and Indolesen_US
dc.typeArticleen_US

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