Synthesis of some newer derivatives of 2-amino benzoic acid as potent anti-inflammatory and analgesic agents.

dc.contributor.author	Bajaj, Kiran
dc.date.accessioned	2021-11-11T11:24:42Z
dc.date.available	2021-11-11T11:24:42Z
dc.date.issued	2003-11-01
dc.description.abstract	Diazotization of N-benzylidene anthranilic acids 1a-1n at pH 9 yielded N-[alpha-(phenylazo) benzylidene] anthranilic acids 2a-2n and at pH 3 yielded N-benzylidene-5-(phenylazo) anthranilic acids 3a-3n. When compounds 3a-3n were treated with thioglycolic/thiolactic acid in the presence of anhydrous ZnCl(2), 2-(4-oxo-2-phenylthiazolidin-3-yl)-5-(phenylazo) benzoic acids 4a-4n were afforded. The newly synthesized compounds were screened for their anti-inflammatory and analgesic activities and were compared with standard drugs, aspirin and phenylbutazone. Out of the compounds studied, the most active compound 4n showed more potent activity than the standard drugs at all doses tested.	en_US
dc.identifier.uri	https://europepmc.org/article/med/14604692
dc.identifier.uri	http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/3517
dc.language.iso	en	en_US
dc.publisher	PMC	en_US
dc.subject	Chemistry	en_US
dc.subject	Synthesis	en_US
dc.subject	Anti-inflammatory	en_US
dc.subject	Analgesic agents	en_US
dc.title	Synthesis of some newer derivatives of 2-amino benzoic acid as potent anti-inflammatory and analgesic agents.	en_US
dc.type	Article	en_US

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