Palladium-catalyzed regioselective C-arylation and C, N-diarylation of N-Aryl-2, 3-dihydrophthalazine-1, 4-diones using diaryliodonium salts

Abstract

Regioselective C-arylation and C,N-diarylation in 2-aryl-2,3-dihydrophthalazine-1,4-diones has been successfully accomplished with diaryliodonium salts under base-mediated slightly modified Pd-catalyzed conditions. These ligand-driven transformations provided a variety of diversely decorated bi(hetero)aryls in good-to-excellent yields, while N-arylated product could be obtained under similar Pd-catalyzed conditions in the absence of a ligand.