Synthesis of Quinazolinones, Imidazo[1,2-c]quinazolines and Imidazo[4,5-c]quinolines through Tandem Reductive Amination of Aryl Halides and Oxidative Amination of C(sp3)–H Bonds

Abstract

The synthesis of quinazolinones, imidazo[1,2-c]quinazolines and imidazo[4,5-c]quinolones has been achieved through a multicomponent copper-catalyzed reaction using easily available sodium azide as a nitrogen source, and DMA (N,N-dimethylacetamide) as a one-carbon source. N-Fused heterocycles were obtained in good to excellent yields, and the reaction is suitable for gram-scale synthesis.