Nanosized Magnesium Oxide as Catalyst for the Rapid and Green Synthesis of Substituted 2-Amino-2-Chromenes

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Date

2007

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EPA

Abstract

A nanosized magnesium oxide catalyzed three-component condensation reaction of aldehyde, malononitrile, and α-naphthol proceeded rapidly in water–PEG to afford corresponding 2-amino-2-chromenes in high yields at room temperature. The greener protocol was found to be fairly general and the catalyst was reused in subsequent reactions with consistent activity.

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Chemistry, Multi-component condensation, Magnesium Oxide, 2-Amino-2-Chromenes

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