Synthesis and anti-angiogenic activity of benzothiazole, benzimidazole containing phthalimide derivatives

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dc.contributor.authorMajumder, Syamantak
dc.date.accessioned2021-10-02T17:48:40Z
dc.date.available2021-10-02T17:48:40Z
dc.date.issued2013
dc.description.abstractBenzothiazole and benzimidazole containing phthalimide derivatives (NK037, NK041, NK042, NK0139A and NK0148) have been synthesized and their anti-angiogenic activity was evaluated using ex vivo egg yolk angiogenesis model. A comparative study with pure thalidomide (NKTA) has also been performed to describe the efficacy of these derivatives in blocking angiogenesis. NK037, NK041 and NK042 were equally potent in blocking egg yolk angiogenesis and the anti-angiogenesis effect was higher than NKTA suggesting the efficacy of these three derivatives in blocking angiogenesis when compare to control. Other two derivatives NK0139A and NK0148 showed effect less than NKTA and stronger than control in ex vivo angiogenesis.en_US
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0960894X12014084?via%3Dihub
dc.identifier.urihttp://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/2428
dc.language.isoenen_US
dc.publisherElsieveren_US
dc.subjectBiologyen_US
dc.subjectThalidomideen_US
dc.subjectAnti-angiogenesisen_US
dc.subjectPhthalimideen_US
dc.titleSynthesis and anti-angiogenic activity of benzothiazole, benzimidazole containing phthalimide derivativesen_US
dc.typeArticleen_US

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