A Facile Synthesis of Novel Bis-(indolyl)-1,3,4-oxadiazoles as Potent Cytotoxic Agents
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Date
2012-09-20
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Wiley
Abstract
A novel series of bis(indolyl)-1,3,4-oxadiazoles was prepared from the corresponding hydrazide-hydrazones via iodobenzene diacetate-promoted oxidative cyclization. Evaluation against a panel of human cancer cell lines revealed that some derivatives possess potent cytotoxicity with tunable selectivity for different cancer types.
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Keywords
Chemistry, Synthesis, Novel Bis-(indolyl)-1,3,4-oxadiazoles, Potent Cytotoxic Agents