A facile Garratt–Braverman cyclization route to intercalative DNA-binding bis-quinones
| dc.contributor.author | Addy, Partha Sarathi | |
| dc.date.accessioned | 2021-11-11T10:55:28Z | |
| dc.date.available | 2021-11-11T10:55:28Z | |
| dc.date.issued | 2012-01-04 | |
| dc.description.abstract | Bispropargyl ethers (both symmetrical and non-symmetrical) equipped with 1,4-dimethoxyaryl groups were synthesized. Under strongly basic conditions (KOBut/toluene/reflux), these ethers underwent Garratt–Braverman type cyclization to the tetramethoxy bi-aryl systems in high yields presumably via the bisallenes. The products could be successfully converted to the bis-quinones via CAN-mediated demethylation cum oxidation. This two-step protocol offers a simple route to bis-quinones, connected by C1–C2′ bonds, in good yields. Fluorescence based EB-displacement assay, CD spectroscopy and viscosity measurements confirmed the DNA-binding ability of the synthesized quinones via intercalation. | en_US |
| dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0040403911017515 | |
| dc.identifier.uri | http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/3309 | |
| dc.language.iso | en | en_US |
| dc.publisher | Elsiever | en_US |
| dc.subject | Chemistry | en_US |
| dc.subject | Garratt–Braverman | en_US |
| dc.subject | DNA-binding | en_US |
| dc.title | A facile Garratt–Braverman cyclization route to intercalative DNA-binding bis-quinones | en_US |
| dc.type | Article | en_US |
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