Packaging of Non-Injectable Liquid Pharmaceuticals: A Review

Abstract

Stability of the pharmaceutical product is strongly influenced by the type and material of packaging, thereby it is gaining substantial attention during the formulation development. Selection of suitable packaging material depends upon several factors which include type of dosage form, route of administration, chemical nature of the active pharmaceutical ingredients and excipient used in the formulations. Non-injectable liquid formulations such as elixirs, suspensions, syrups etc are less susceptible to interaction with packaging material when compared to that of the injectable formulations, probably due to the difference in processing conditions used during the formulation development. In the present review, we focus on the packaging aspects of non-injectable liquid formulations. Different packaging materials, which can be used for packaging of non-injectable liquid formulation are discussed. Regulatory aspects of Unlisted State Food and Drug Administration [USFDA] and European Medicines Agency [EMA] are also highlighted. Additionally, packaging of non-injectable liquid formulation for pediatric use is discussed.