[P2–130]: AR-A014418, A GSK-3β INHIBITOR, ATTENUATES ALZHEIMER'S- LIKE PATHOLOGY IN HIGH FAT DIET-INDUCED COGNITIVE DEFICIT IN MICE
| dc.contributor.author | Taliyan, Rajeev | |
| dc.date.accessioned | 2023-12-14T06:54:46Z | |
| dc.date.available | 2023-12-14T06:54:46Z | |
| dc.date.issued | 2017-07 | |
| dc.description.abstract | Alzheimer's disease (AD) is characterized by the progressive deposition of fibrillar amyloid-β (Aβ) in the form of extracellular plaques and hyperphosphorylated tau as intraneuronal neuro fibrillary tangles (NFTs). Studies have reported that increased Glycogen synthase kinase-3β (GSK-3β) activity has been associated with hyper phosphorylation of tau. However, the molecular mechanisms of association still remain elusive. Thus, the present study was designed to explore the potential of GSK-3β inhibitor, AR-A014418 in high fat diet (HFD) induced cognitive impairment and AD like pathology. | en_US |
| dc.identifier.uri | https://alz-journals.onlinelibrary.wiley.com/doi/full/10.1016/j.jalz.2017.06.780 | |
| dc.identifier.uri | http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/13421 | |
| dc.language.iso | en | en_US |
| dc.publisher | Wiley | en_US |
| dc.subject | Pharmacy | en_US |
| dc.subject | Alzheimer's disease (AD) | en_US |
| dc.subject | Glycogen synthase kinase-3β | en_US |
| dc.subject | High Fat Diet (HFD) | en_US |
| dc.title | [P2–130]: AR-A014418, A GSK-3β INHIBITOR, ATTENUATES ALZHEIMER'S- LIKE PATHOLOGY IN HIGH FAT DIET-INDUCED COGNITIVE DEFICIT IN MICE | en_US |
| dc.type | Article | en_US |
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