A new receptor with a FRET based fluorescence response for selective recognition of fumaric and maleic acids in aqueous medium

Abstract

Preferential binding of a new reagent to fumaric acid could be utilized for its estimation in aqueous medium and in commercial fruit juice.Molecular recognition studies of dicarboxylic acids have gained importance because of their presence as key structural moieties in many bioactive molecules, their role in various metabolic processes and involvement in the biosynthesis of some important intermediates.1 Fumaric (Fum) and maleic (Mal) acids find a broad range of uses in medicine, food and polymer industries.1 More recently, fumaric acid derivatives have been tested for treatment of multiple sclerosis and patients with psoriasis.2 Maleic acid is known for its role as an inhibitor of the Krebs cycle and in different kidney diseases.2 Due to the widespread use of these two acids as ingredients in food as well as beverages and their possible adverse influences on human health upon prolonged exposure, it is important to develop an efficient reagent for their recognition and quantitative estimation in aqueous medium