Recent developments in the catalytic asymmetric synthesis of indolin-3-one derivatives

Abstract

2,2-Disubstituted indolin-3-ones, which are essential components in many manufactured chemicals, dyes, and naturally occurring bioactive alkaloids, have emerged as exciting synthetic targets. Much attention has been paid to accessing these units, particularly in an asymmetric fashion, during the last decade. In this review article, we discuss the current state of available methods with existing mechanistic pathways for accessing chiral indolin-3-one derivatives under various catalytic systems. This overall presentation of asymmetric catalytic protocols to access 2,2-disubstituted or fused indolin-3-ones with an aza-quaternary centre is categorized based on the reaction modes of 2-substituted-3H-indole-3-one derivatives or other similar protocols.