A Facile and Expeditious One-Pot Synthesis of α-Keto-1,3,4-oxadiazoles
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Date
2014
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Publisher
Thieme
Abstract
A 2-iodoxybenzoic acid/tetraethylammonium bromide mediated oxidative cyclization of hydrazide-hydrazones generated in situ from aryl glyoxal and hydrazides enables an efficient and high-yielding protocol for the preparation of α-keto-1,3,4-oxadiazoles under mild conditions in short reaction times.
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Keywords
Chemistry, Synthesis