Natural HDAC Inhibitors: Nature’s Answer to the Cancer

Abstract

Post translational modifications of histones play a significant role in regulation of physiological and pathological processes in the body. Acetylation is one of the most important chromatin modifying mechanisms being controlled by histone acetyl transferases and histone deacetylases. The histone deacetylases (HDAC) are basically responsible for silencing of gene transcription. Cancer involves silencing of a large number of genes. Inhibition of such gene silencing could possibly lead us to alleviatin or control of cancer progression. Natural HDAC inhibitors, a highly researched topic thus seems an attractive method to conquer the kingdom of cancer and thus prove to be the ‘bull’s eye’ like target for cancer treatment