Novel porphyrin–psoralen conjugates: synthesis, DNA interaction and cytotoxicity studies
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Date
2013
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Journal ISSN
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Publisher
RSC
Abstract
A Cu(I)-catalyzed azide–alkyne cycloaddition reaction (CuAAC) has been utilized to prepare novel triazole-linked cationic porphyrin–psoralen conjugates that exhibited significant photocytotoxicity against A549 cancer cells (IC50 = 84 nM).
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Keywords
Chemistry, Novel porphyrin–psoralen, Synthesis, DNA interaction