Organocatalytic Mannich/cyclization/aromatization sequence: direct synthesis of substituted pyrrole-3-carboxaldehydes
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Date
2012
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Publisher
RSC
Abstract
A robust method for the synthesis of substituted pyrrole-3-carboxaldehydes from N-PMP aldimines and succinaldehyde is reported. This reaction involves an organocatalytic direct Mannich reaction, and an acid catalyzed cyclization and oxidative aromatization sequence with high yields (up to 82%).
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Keywords
Chemistry, Organocatalytic, Mannich/cyclization/aromatization, Pyrrole-3-carboxaldehydes