Biodegradable nanogels for dermal applications: an insight

Abstract

Biodegradable nanogels in the biomedical field are emerging vehicles comprising dispersions of hydrogel nanoparticles having 3D crosslinked polymeric networks. Nanogels show distinguished characteristics including their homogeneity, adjustable size, low toxicity, stability in serum, stimuli-responsiveness (pH, temperature, enzymes, light, etc.), and relatively good drug encapsulation capability. Due to these characteristics, nanogels are referred to as nextgeneration drug delivery systems and are suggested as promising carriers for dermal applications. The site-specific delivery of drugs with effective therapeutic effects is crucial in transdermal drug delivery. The nanogels made from biodegradable polymers can show external stimuliresponsiveness which results in a change in gel volume, water content, colloidal stability, mechanical strength, and other physical and chemical properties, thus improving the site-specific topical drug delivery. This review provides insight into the advances in development, limitations, and therapeutic significance of nanogels formulations. It also highlights the process of release of drugs in response to external stimuli, various biodegradable polymers in the formulation of the nanogels, and dermal applications of nanogels and their role in imaging, anti128;inflammatory therapy, antifungal and antimicrobial therapy, anti128;psoriatic therapy, and ocular and protein/peptide drug delivery.