Scale-Up of Liquid Mixing Process

Abstract

To meet the growing demands of production and reduce costs, it is necessary to increase the scale of production. However, transferring the lab-scale process to a large manufacturing scale can be a challenging task for trained personnel. The manufacturing process, which involves homogeneous or heterogeneous systems, requires several scale-up parameters to be considered when designing large-scale production. These parameters include power requirements, volume measurement, vessel design, mixing device speed, and any other equipment that affects the flow and mixing quality. In this chapter, we will discuss the basics of fluid motion, factors that affect it, mixing devices, and auxiliary equipment that assists liquid mixing. We will also provide an overview of the various approaches to scientific scale-up, including relevant equations and an illustrative example.