Newer Substituted Benzoxazepinylquinazolinones as Potent Antipsychotic and Anticonvulsant Agents

Abstract

3-Amino-[2’-substitutedaryl-3’-substitutedarylaminomethylene-2’,3’-dihydro-1’,5’-benzoxazepin-4’-yl]-2-methylquinazolin-4(3H)-ones 11−18 and 3-amino-[2’-substituted aryl-3’-substitutedaryl-azo-2’,3’-dihydro-1’,5’-benzoxazepin-4’-yl]-2-methyl-quinazolin-4(3H)-ones 19− 26 were synthesized from 3-amino-[2’-substitutedaryl-2’,3’-dihydro-1’,5’-benzoxazepin-4’-yl]-2-methyl-quinazolin-4(3H)-ones 7−10 by Mannich’s reaction and by diazotisation, respectively, on the 3rd position of the benzoxazepine ring of the compounds 7−10. The newly synthesized compounds showed potent antipsychotic and anticonvulsant activities.