Hyaluronic acid functionalized liposomes embedded in biodegradable beads for duo drugs delivery to oxaliplatin-resistant colon cancer
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Date
2022-11
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Elsevier
Abstract
Oxaliplatin (OHP) resistance is a major hurdle in the chemotherapeutic treatment of colorectal cancer (CRC). The present study aimed to formulate Eudragit S-100 (ES-100) coated alginate beads bearing drugs loaded targeted liposomes for simultaneous delivery of OHP and curcumin (CUR) to exert a synergistic therapeutic effect on OHP- resistant HT-29 cell line
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Keywords
Pharmacy, Box-behnken design, Colorectal cancer, Curcumin, Hyaluronic acid liposomes