Synthesis of highly efficient pH-sensitive DNA cleaving aminomethyl N-substituted cyclic enediyne and its L-lysine conjugate

dc.contributor.author	Addy, Partha Sarathi
dc.date.accessioned	2021-11-11T10:55:41Z
dc.date.available	2021-11-11T10:55:41Z
dc.date.issued	2013-02-20
dc.description.abstract	Two 10-membered benzo-fused N-substituted cyclic enediynes, one an amino methyl and the other, a C-lysine conjugated derivative 2 and 3, respectively were synthesized (as a 1.2:1 mixture of regioisomers) and their DNA-cleavage efficiency studied. Both the compounds showed much better DNA-cleavage profile than that of the parent unsubstituted enediyne 1. The lysine conjugate 3 showed an efficient pH dependent cleavage to the extent of ∼50% of linear DNA formation under ambient conditions.	en_US
dc.identifier.uri	https://www.sciencedirect.com/science/article/pii/S0040403912020655
dc.identifier.uri	http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/3312
dc.language.iso	en	en_US
dc.publisher	Elsiever	en_US
dc.subject	Chemistry	en_US
dc.subject	Synthesis	en_US
dc.subject	L-lysine conjugate	en_US
dc.title	Synthesis of highly efficient pH-sensitive DNA cleaving aminomethyl N-substituted cyclic enediyne and its L-lysine conjugate	en_US
dc.type	Article	en_US

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