Synthesis of Pyrazolo[3,4-d]pyrimidine Derivatives and Evaluation of their Src Kinase Inhibitory Activities

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dc.contributor.authorKumar, Anil
dc.date.accessioned2021-10-17T13:59:25Z
dc.date.available2021-10-17T13:59:25Z
dc.date.issued2013
dc.description.abstractA series of pyrazolo[3,4-d]pyrimidine derivatives was synthesized and evaluated for the Src kinase inhibitory activities. Compound 6e and 10c exhibited inhibition of Src kinase with an IC50 value of 5.6 and 5.1 μM, respectively. Hydroxamate derivative 15a was found to be a metal-mediated inhibitor for human Csk with an IC50 value of 2.0 μM showing 56-fold selectivity over Src kinase inhibition.en_US
dc.identifier.urihttps://digitalcommons.chapman.edu/pharmacy_articles/89/
dc.identifier.urihttp://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/2900
dc.language.isoenen_US
dc.publisherISCBen_US
dc.subjectChemistryen_US
dc.subjectSynthesisen_US
dc.subjectAnticancer agentsen_US
dc.subjectPyrazolo[3,4-d]pyrimidine,en_US
dc.titleSynthesis of Pyrazolo[3,4-d]pyrimidine Derivatives and Evaluation of their Src Kinase Inhibitory Activitiesen_US
dc.typeArticleen_US

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