Amino Acyl Conjugates of Nitrogen Heterocycles as Potential Pharmacophores

Abstract

2-Methyl- and 4-methylpyridine and 2-methylquinoline are converted by benzotriazole-activated (Cbz)-protected amino acids into chiral potential novel pharmacophore aminoacyl conjugates (33−53%). α-Amino acids and their derivatives are central to the chemistry and biology of peptides and proteins as well as versatile synthetic building blocks for pharmaceutical applications, precursors for the generation of molecular diversity, important templates in asymmetric catalysis, and common subunits in many bioactive compounds and natural products