A Novel and Efficient One Pot Synthesis of 2,4-Disubstituted Thiazoles and Oxazoles Using Phenyltrimethylammoniumtribromide in Ionic Liquid
No Thumbnail Available
Date
2012-09-10
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Wiley
Abstract
A novel and efficient one-pot procedure has been described for synthesis of 2,4-disubstituted thiazoles and oxazoles from substituted ketones using phenyltrimethylammoniumtribromide as in situ brominating agent followed by reaction with thioamide/thiourea and amides/ureas, respectively in [bmim][BF4] ionicliquid. The advantages of the procedure include avoiding the handling of lacrymetric compounds, hazardous and toxic organic solvents along with good to excellent yield of the products.
Description
Keywords
Chemistry, Thiazoles, Oxazoles, Phenyltrimethylammoniumtribromide