Organo-catalyzed enantioselective [4+2] Annulation of glutaraldehyde and c3-indolyl-imines to access indol-3-yl-piperidines

Simple item page
dc.contributor.authorKumar, Indresh
dc.date.accessioned2025-07-25T07:09:09Z
dc.date.available2025-07-25T07:09:09Z
dc.date.issued2023-10
dc.description.abstractA simple and straightforward method is developed for the enantioselective synthesis of indol-3-yl-piperidine. The reaction proceeds through a proline-catalyzed direct Mannich reaction between glutaraldehyde and C3-indolyl-imines, followed by intramolecular reductive cyclization as an overall [4+2] annulation in one-pot fashion. A series of indol-3-yl-piperidine have been accessed with good yields up to 71 % and high enantioselectivity up to >99 % ee.en_US
dc.identifier.urihttps://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/ejoc.202300901
dc.identifier.urihttps://dspace.bits-pilani.ac.in/handle/123456789/19091
dc.language.isoenen_US
dc.publisherWileyen_US
dc.subjectChemistryen_US
dc.subjectIndol-3-yl-piperidineen_US
dc.subjectEnantioselective synthesisen_US
dc.subjectReductive cyclizationen_US
dc.subjectGlutaraldehydeen_US
dc.titleOrgano-catalyzed enantioselective [4+2] Annulation of glutaraldehyde and c3-indolyl-imines to access indol-3-yl-piperidinesen_US
dc.typeArticleen_US

Files

License bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Department of Chemistry