Quinine bis-conjugates with quinoloneantibiotics and peptides: synthesis and antimalarial bioassay

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dc.contributor.authorBajaj, Kiran
dc.date.accessioned2021-11-11T11:23:36Z
dc.date.available2021-11-11T11:23:36Z
dc.date.issued2012
dc.description.abstractBenzotriazole-mediated syntheses led to novel bis-conjugates of quinine with quinolone antibiotics and amino acid linkers which were successfully prepared by two alternative routes with excellent yields and retention of chirality. These bis conjugates retain in vitro antimalarial activity with IC50 values ranging from 12 to 207 nM, similar to quinine itself.en_US
dc.identifier.urihttps://pubs.rsc.org/en/content/articlelanding/2012/OB/c2ob26439k
dc.identifier.urihttp://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/3505
dc.language.isoenen_US
dc.publisherRSCen_US
dc.subjectChemistryen_US
dc.subjectQuinine bis-conjugatesen_US
dc.subjectQuinoloneantibioticsen_US
dc.subjectPeptidesen_US
dc.subjectSynthesisen_US
dc.subjectAntimalarial bioassayen_US
dc.titleQuinine bis-conjugates with quinoloneantibiotics and peptides: synthesis and antimalarial bioassayen_US
dc.typeArticleen_US

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