Synthesis and biological evaluation of novel carbazolyl glyoxamides as anticancer and antibacterial agents

dc.contributor.author	Kumar, Dalip
dc.date.accessioned	2021-10-27T04:19:46Z
dc.date.available	2021-10-27T04:19:46Z
dc.date.issued	2016
dc.description.abstract	A new library of 24 carbazolyl glyoxamides 14a–x were designed and synthesized from glyoxalic acids and arylamines in the presence of HATU as a coupling reagent under MW irradiation. The synthesized carbazolyl glyoxamides were evaluated for their in vitro anticancer and antibacterial activities. Of the synthesized carbazolyl glyoxamides, compounds 14l and 14q exhibited the most potent cytotoxicity towards a breast cancer cell line with IC50 values of 9.3 and 9.8 μM, respectively. Further, caspase-3 assay for carbazolyl glyoxamides indicated that these compounds induced apoptotic cell death in Jurkat cells. Furthermore, some of the synthesized carbazolyl glyoxamides 14g, 14k, 14l and 14n exhibited comparable or even better antibacterial activity (MIC = 8–16 μg mL−1) than chloramphenicol against the selected bacterial strains	en_US
dc.identifier.uri	https://pubs.rsc.org/en/content/articlelanding/2016/ra/c5ra27175d
dc.identifier.uri	http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/3032
dc.language.iso	en	en_US
dc.publisher	RSC	en_US
dc.subject	Chemistry	en_US
dc.subject	Synthesis	en_US
dc.subject	Anticancer	en_US
dc.subject	Glyoxamides	en_US
dc.title	Synthesis and biological evaluation of novel carbazolyl glyoxamides as anticancer and antibacterial agents	en_US
dc.type	Article	en_US

Files

Now showing 1 - 1 of 1