Ionic Liquid-Supported Aldehyde: A Highly Efficient Scavenger for Primary Amines

Abstract

Novel aldehyde-functionalized ionic liquids have been synthesized and used as scavengers for primary amines in the synthesis of secondary amines. The yields of secondary amines are high (82–90%) with high purity. The advantages of the protocol over that with a polymer-supported aldehyde scavenger are the shorter reaction time, the homogeneous reaction medium, the high level of loading of the aldehyde group, easy monitoring of reaction, and characterization of intermediates.