Metformin and glitazones: does similarity in biomolecular mechanism originate from tautomerism in these drugs?

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dc.contributor.authorSundriyal, Sandeep
dc.date.accessioned2024-01-17T09:02:59Z
dc.date.available2024-01-17T09:02:59Z
dc.date.issued2007-11
dc.description.abstractThis theoretical study attempts to find out similarity between metformin and glitazone class of antidiabetic drugs. It was found that some tautomeric forms of both metformin and thiazolidinedione ring of glitazones have similar molecular electrostatic potential (MESP) surface and may bind to a common complementary surface. Complexation and docking studies were also carried out in order to support this hypothesis.en_US
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/abs/10.1002/poc.1273
dc.identifier.urihttps://dspace.bits-pilani.ac.in/xmlui/handle/123456789/13862
dc.language.isoenen_US
dc.publisherWileyen_US
dc.subjectPharmacyen_US
dc.subjectBiomolecular mechanismen_US
dc.subjectMetforminen_US
dc.subjectGlitazonesen_US
dc.titleMetformin and glitazones: does similarity in biomolecular mechanism originate from tautomerism in these drugs?en_US
dc.typeArticleen_US

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