Synthesis of meso-(4′-cyanophenyl) porphyrins: efficient photocytotoxicity against A549 cancer cells and their DNA interactions

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dc.contributor.authorKumar, Anil
dc.contributor.authorKumar, Dalip
dc.date.accessioned2021-10-17T13:56:38Z
dc.date.available2021-10-17T13:56:38Z
dc.date.issued2015
dc.description.abstractWe report a facile iodine(III)-mediated synthesis of cyanoporphyrins and their DNA photocleavage activity. Cationic-porphyrin 9a showed intercalative binding towards DNA, whereas Zn(II)-cyanoporphyrinate 9b showed outside electrostatic binding as indicated by their absorption and emission spectra. Porphyrin 9a displayed significant photocytotoxicity against A549 cancer cell line with an IC50 value of 54 nM.en_US
dc.identifier.urihttps://pubs.rsc.org/En/content/articlelanding/2015/ra/c5ra03075g
dc.identifier.urihttp://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/2861
dc.language.isoenen_US
dc.publisherRSCen_US
dc.subjectChemistryen_US
dc.subjectMeso-(4′-cyanophenyl) porphyrinsen_US
dc.subjectCancer cellsen_US
dc.subjectPhotocytotoxicityen_US
dc.titleSynthesis of meso-(4′-cyanophenyl) porphyrins: efficient photocytotoxicity against A549 cancer cells and their DNA interactionsen_US
dc.typeArticleen_US

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