New PPARγ ligands based on barbituric acid: Virtual screening, synthesis and receptor binding studies

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dc.contributor.authorSundriyal, Sandeep
dc.date.accessioned2024-01-17T04:42:16Z
dc.date.available2024-01-17T04:42:16Z
dc.date.issued2008-09
dc.description.abstractA new series of PPARγ ligands based on barbituric acid (BA) has been designed employing virtual screening and molecular docking approach. To validate the computational approach, designed molecules were synthesized and evaluated in in vitro radioligand binding studies. Out of the total 14 molecules, 6 were found to bind to the murine PPARγ with IC50 ranging from 0.1 to 2.5 μM as compared to reference standard, pioglitazone (IC50 = 0.7 μM).en_US
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0960894X08009505
dc.identifier.urihttp://dspace.bits-pilani.ac.in:8080/jspui/xmlui/handle/123456789/13851
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectPharmacyen_US
dc.subjectPPARγen_US
dc.subjectVirtual screeningen_US
dc.subjectDockingen_US
dc.subjectDiabetesen_US
dc.subjectBarbituric aciden_US
dc.subjectRosiglitazoneen_US
dc.titleNew PPARγ ligands based on barbituric acid: Virtual screening, synthesis and receptor binding studiesen_US
dc.typeArticleen_US

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