Oncostatin M upregulates HIF-1α in breast tumor associated macrophages independent of intracellular oxygen concentration
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Date
2018-02
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Elsevier
Abstract
HIF is an important transcription-regulator for adaptation to cellular stress in cells of myeloid origin. Classically, expression and activity of HIF1-α is regulated by oxygen-concentration within cell. However, there exists an alternative regulatory mechanism affecting HIF1-α levels independent of oxygen concentration particularly in inflammatory cells like macrophages. Here we report the mechanism of HIF1-α upregulation in TAMs by Oncostatin-M (OSM) independent of cellular oxygen concentration.
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Keywords
Pharmacy, TAMs, Oncostatin M, HIF-1α, Normoxia, M2 macrophages